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pentobarbital raises toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers could increase the metabolism of ifosfamide to its Lively alkylating metabolites.pentobarbital will minimize the level or influence of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify The